Microdose.

What a microdose is.

The same molecule, at a lower dose.

Microdose semaglutide and microdose tirzepatide use the same active ingredients as the standard injectables, prescribed at a lower dose and on a more gradual schedule. Both are compounded with vitamin B12 by a licensed 503A pharmacy.

Some clinicians use lower-dose protocols for patients who prefer a more gradual introduction. There is no FDA-approved dosing for microdose protocols, so your clinician sets your dose from your intake and adjusts it over time. Your prescription label lists your exact dose and schedule.

Semaglutide or tirzepatide.

Semaglutide is a GLP-1 receptor agonist, acting on the receptors the body’s own GLP-1 hormone acts on. Tirzepatide acts on two incretin pathways rather than one, GIP and GLP-1.

Which one is appropriate is a clinical decision, not a preference. It depends on your history, your current medications, and how your body responds over time.

Compounded, not FDA-approved.

Both microdose options are prepared by licensed 503A pharmacies against a patient-specific prescription. Compounded medications are not reviewed or approved by the FDA for safety, effectiveness, or quality, and they are not the same product as the brand-name versions, Wegovy® and Zepbound®. They are also not generics — no generic semaglutide or tirzepatide exists.

What’s included.

Every plan includes the medication, injection supplies, the clinician consultation and review, ongoing clinician oversight, and shipping. No membership, no hidden fees. You are not charged unless a clinician approves treatment.

Both come in monthly and quarterly plans. Prices are on the cards above.

Who it isn’t for.

A microdose uses the same active ingredient at a lower dose. The same cautions apply as for the standard forms, and a clinician will tell you if it isn’t for you.

Do not use either medication if you or a family member have ever had medullary thyroid carcinoma (MTC), or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), or if you have had a serious allergic reaction to semaglutide, tirzepatide or any ingredient in the medication. Both may harm an unborn baby, so they are stopped if you become pregnant, and semaglutide is stopped at least two months before a planned pregnancy.

Tirzepatide can make birth control pills less effective. If you use them, your clinician will advise switching to a non-oral method or adding a barrier method for four weeks after you start and after each dose increase.

Tell your clinician about past pancreatitis, gallbladder or kidney problems, slowed stomach emptying, or diabetic eye disease. Full details are on each product’s safety information page.

“Not yet” and “not for you” are real answers here, and you won’t be charged for hearing one.